In a renal cell carcinoma cell line, nc886 knockdown similarly led to increased apoptosis and decreased cell proliferation, whereas overexpression led to increased proliferation and invasion apparently in part through activation of the JAK2/STAT3 pathway, as treatment of the cells with a JAK2 inhibitor attenuated the nc886 overexpression-derived phenotypes (Lei et al. 2017). This evidence concerns the gene JAK2 and renal cell carcinoma.