Like that of BRF1, expression of BRF2 was increased when primary human IMR90 fibroblasts were transformed with successive defined genetic steps (Durrieu-Gaillard et al. 2018), and BRF2 expression was found increased in Oncomine data sets from melanoma as well as gastric and kidney cancers (Cabarcas and Schramm 2011). This evidence concerns the gene BRF2 and melanoma.