BCYRN1 and ovarian cancer: Although one study reports down-regulation of BC200 in ovarian cancer tissues and in ovarian cancer cell lines (Wu et al. 2016), others have observed elevated levels of BC200 in such tumors and decreased viability of several cancer cell lines, including an ovarian cancer cell line examined by Wu et al. (2016), upon BC200 knockdown (Chen et al. 1997; Booy et al. 2017).