BRF2 and kidney cancer: Like that of BRF1, expression of BRF2 was increased when primary human IMR90 fibroblasts were transformed with successive defined genetic steps (Durrieu-Gaillard et al. 2018), and BRF2 expression was found increased in Oncomine data sets from melanoma as well as gastric and kidney cancers (Cabarcas and Schramm 2011).