TPMT and acute lymphoblastic leukemia: Figure 3 shows the AUCs representing the diagnostic accuracies of the traditional two-gene prediction model (GVBNUDT15,TPMT, left panels in the figure) and the newly introduced three-gene prediction model (GVBNUDT15,TPMT,CRIM1, right panels in the figure) across all seven DIP cutoffs (≤ 15%, ≤ 25%, ≤ 35%, ≤ 45%, ≤ 60%, ≤ 80%, and ≤ 100%) in the discovery (N = 244), replication (N = 76), and combined (N = 320) pediatric ALL cohorts.