Advanced age (> 70 years), male sex, lung cancer, poor performance status, leukocytosis, neutrophilia, lymphopenia, thrombocytopenia, azotemia, hypoalbuminemia, hyperbilirubinemia, prolonged prothrombin time (PT)-INR, elevated CRP, and hypernatremia were associated with significantly shorter median survival time. The gene discussed is CRP; the disease is Hypernatremia.