There were no significant differences between the two groups including age, gender, operative time, blood loss, operative procedure, operative method, surgical margin, tumor size, number of tumor, differentiation, MVI classification, envelope invasion, cirrhosis (fibrosis Scheuer S score), viral hepatitis (HBV-Ag), preoperative serum AFP, alanine aminotransferase (ALT), total bilirubin (TBIL), albumin (ALB) and prothrombin time (PTa). The gene discussed is AFP; the disease is viral hepatitis.