In a parabiosis model, ischemia-reperfusion injury modulates intracerebral hemorrhage resolution via AMPK, which was thought most likely to be mediated by transferred leukocytes.21 Here, we here define a direct and local intrinsic hemorrhage-resolution mechanism, driven via an AMPK-ATF1 pathway by the hematoma itself. The gene discussed is PRKAB1; the disease is intracerebral hemorrhage.