CUL3 and intracerebral hemorrhage: Since thrombin, via PAR‐1 and cullin 3‐mediated degradation is known to promote post‐transcriptional downregulation of ABCA1 in macrophages,48 and is also known to promote M1 polarization of microglia after intracerebral hemorrhage,49 our data are most consistent with the hypothesis that thrombin plays a hitherto unrecognized but pivotal role in determining the inflammatory phenotype of plaque macrophages and promoting plaque progression.