Besides, a range of specific proteins on the surface of CTCs, including GPC3, asialoglycoprotein receptor (ASGPR), and hepatocyte paraffin 1 (Hep Par 1), was shown to provide diagnostic and prognostic information on HCC progression for its early detection and prognostication, as well as prediction and monitoring for treatment responsiveness. This evidence concerns the gene ASGR1 and hepatocellular carcinoma.