NOTCH2 and colorectal carcinoma: Several studies indicate that miR-195-5p can increase the sensitivity of 5FU-resistant SW620 and HT-29 cell lines to chemotherapy by targeting transcriptional regulators, notch receptor 2 (NOTCH2) and recombination signal binding protein for immunoglobulin kappa J region (RBPJ) involved in the Notch signalling pathway, both of which are necessary for the maintenance of stemness and chemoresistance in CRC cells [174].