As regards the top-ten downregulated genes, three of them (i.e., ADGRD1, NPR3, GPM6A) were involved in G-protein coupled receptor (GPCR) signaling pathways, including those attributable to HCC; another one (GPM6A) may contribute to the regulation of endocytosis and intracellular trafficking of GPCRs. This evidence concerns the gene ADGRD1 and hepatocellular carcinoma.