MAPT and Alzheimer disease: In addition to the pathological hallmarks of the disease, such as the accumulation of misfolded protein deposits in the brain as extracellular plaques containing amyloid β-peptides (Aβs) and intraneuronal neurofibrillary tangles formed by hyperphosphorylated tau proteins, AD brains exhibit evidence of reactive oxygen species (ROS)-mediated injury [4].