HSPA5 and Alzheimer disease: Intriguingly, the majority of the proteins have catalytic, binding, or hydrolase activities, which are exploited in important cellular processes, such as energy metabolism (Dhpr, Pgam1, Idh3, and Atp5a1), protein folding (GRP78, Sec23ip), degradation processes (Arel1, Lsm11), and cell structure (Dpyl2, Gnb1, Myh10, Ocln, Tpt1), suggesting that their oxidative modification may deeply affect brain physiology, as previously demonstrated in AD [5,6].