One of the most common KRAS mutations, KRAS-G13D, drives glucose uptake by increased expression of GLUT1 next to enhanced lactate production, thereby fostering the Warburg effect as shown in the established isogenic CRC cell lines RKO wild-type/BRAF-V600E and DLD-1 wild-type/KRAS-G13D [42,43,44,45,46]. Here, BRAF is linked to colorectal carcinoma.