The induction of HIF-1α hydroxylation, catalyzed by prolyl hydroxylase domain protein (PHD) [28], and its subsequent protein degradation by zebularine, led to the reversal of oxaliplatin resistance and the inhibition of angiogenesis in an azoxymethane (AOM)/ dextran sodium sulfate (DSS)-induced CRC mouse model [19]. The gene discussed is HIF1A; the disease is colorectal carcinoma.