CD8A and neoplasm: In addition, TGFβ promotes the release of angiogenic factors (such as vascular endothelial growth factor (VEGF)), and the recruitment of Treg cells, neutrophils, macrophages (with pro-tumour polarization), myeloid-derived suppressor cells (MDSC) and tolerogenic DCs, in turn decreasing the functions of NK cells and CD8 T lymphocytes [77].