In the study by Michal Bassani-Sternberg et al. [358] it was postulated that if a significant proportion of sMHC molecules in plasma are released from diseased cells (multiple myeloma, acute myeloid leukaemia and acute lymphoblastic leukaemia) and also carry their original peptide load, analysis of sMHC peptidomes may be an ideal source of biomarkers in various diseases, considering that sMHC peptidomes are similar to membrane MHC peptidomes. The gene discussed is MYH11; the disease is AL amyloidosis.