The use of IFN-α was approved in 1986 for the treatment of hairy cell leukemia [77], as it produced a sustained improvement in granulocyte, platelet count and hemoglobin levels in 77% of LCH patients treated [81] and has since been used in the treatment of hematologic malignancies and solid tumours [77], such as chronic myeloid leukemia, AIDS-related Kaposi’s sarcoma, renal cell cancer, and in the case of stage II and III melanoma has been used as adjuvant therapy [79]. Here, IFNA17 is linked to melanoma.