Compared to the normal kidney cell line HKC-8 (Figure 2A), all the three ccRCC-derived cell lines diverged in terms of EV protein expression: the 786-O cell line (B) presented a higher expression of MMP-1 and a lower expression of TIMP-2, the Caki-1 cell line (C) presented similar expression in terms of TIMP-2 and a slightly higher of TIMP-1, and the RCC-FG2 cell line (D) presented lower expression of TIMP-2 and similar expression of TIMP-1. The gene discussed is MMP1; the disease is nonpapillary renal cell carcinoma.