TIMP1 and metastatic neoplasm: Given the fact that our survival analysis indicated that metastatic patients with higher EV-derived TIMP-1 mRNA present a lower overall survival and that these two patients with elevated EV-derived TIMP-1 mRNA developed metastatic disease within a short period of time, we can hypothesize that the levels of EV-derived TIMP-1 mRNA could be a prognosis biomarker, namely a metastatic disease predictor.