FCGR3A and neoplasm: Recently, several tri-specific killer cell engagers (TriKEs) have been also developed to boost NK cell functions [222,223,224,225,226,227,228,229,230,231,232,233,234].TriKEs work similarly to BiKEs, indeed they bind to an activating receptor expressed on NK cells (e.g., CD16) and to two different antigens expressed on tumor cells; this can lead to the generation of a very strong immunological synapse between tumor and effector cells.