PIK3CA and neoplasm: In addition, PTEN is a dual-specificity protein and lipid phosphatase that regulates various cellular processes and signal pathways, such as the induction of apoptosis by inhibiting phosphatidylinositol 3-kinase (PI3K)/Akt pathway and control of cell adhesion, migration, and tumor invasion, by downregulating the activity of focal adhesion kinases (FAKs) [3].