Menopausal-onset asthma affects 18% of the total female asthma population, and frequently, it is characterized by the absence of atopy; recurrent sinusitis; aspirin sensitivity and/or intolerance to angiotensin-converting enzyme inhibitors, greater severity (use of systemic steroids to control symptoms and frequent hospitalizations) and an altered perception of asthmatic symptoms [11,12]. The gene discussed is ACE; the disease is asthma.