CDK8 and skin neoplasm: Additionally, vanicoside B inhibited two-stage carcinogenesis of mouse skin tumor induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and exhibited antitumor activity against a panel of cancer cell lines in triple-negative breast cancer (TNBC) MDA-MB-231 cells by targeting cyclin-dependent kinase 8 (CDK8) [17].