BRAF and melanoma: Moreover, the V600E BRAF mutation concerns a number of patients, about 50% of melanomas of all clinical types have mutations in the BRAF kinase, mainly the V600E BRAF mutation (70%–80% of all BRAF mutations in all cancers; the remaining 5% to 15% are BRAF V600K, V600D or V600R mutations) [21].