Using adipocyte models, our group reported that twelve different adipocyte-derived miRNAs targeting peroxisome proliferator-activated receptor gamma (PPARγ) (miRNA-31, miRNA-130b and miRNA-23a), adipocyte differentiation (miRNA-143, miRNA-145, miRNA-146a, miRNA-125b, miRNA-222 and miRNA-221), CCAAT/enhancer-binding protein alpha (miRNA-31) and pathways of insulin resistance (miRNA-107 and miRNA-103a) were significantly altered due to low B12, thereby modulating adipocyte differentiation and physiology [41]. This evidence concerns the gene PPARG and Insulin resistance.