Overexpression of extracellular HMGB1 was observed in several neuroinflammatory conditions, including TBI [12], Subarachnoid hemorrhage (SAH) [13], Epilepsy [14], Alzheimer’s diseases (AD) [15], Amyotrophic lateral sclerosis (ALS) [16,17] Parkinson’s diseases (PD) [18], etc. This evidence concerns the gene HMGB1 and amyotrophic lateral sclerosis.