NFKB1 and rheumatoid arthritis: Specifically, this splice variant-induced decrease in BKCa current attenuated histamine-induced cyclooxygenase (COX) 2 gene transcription that is controlled by Ca2+-dependent factors, such as NFAT [34] and NF-κB [35], an effect that may also alter the lubricant secretion by the chondrocyte and its ability to proliferate in settings such as osteoarthritis or rheumatoid arthritis (see Discussion).