It would be suggested that the protective alleles of CFH against AMD promote pachychoroid and subsequent CSC development but promote early resolution of CSC and suppress the progression from CSC to pachychoroid neovasculopathy, while the risk alleles of CFH for AMD promote the progression of pachychoroid neovasculopathy from VIPR2-induced CSC. Here, CFH is linked to age-related macular degeneration.