CSC in a patient with the protective allele of CFH against AMD tends to resolve earlier without treatment; however, in patients with the risk alleles of CFH and ARMS2 for AMD, CSC tends to progress to pachychoroid neovasculopathy through development of CNV even after the resolution of serous retinal detachment due to CSC [7]. This evidence concerns the gene ARMS2 and age-related macular degeneration.