Only one group evaluated risk alleles for AMD in CFH and ARMS2 and reported that risk alleles in CFH and ARMS2 were less frequent in eyes with pachydrusen than eyes with soft drusen (P = 0.0091 and 2.4 × 10−8, respectively), and the risk allele in CFH was significantly less frequent in eyes with pachydrusen than in eyes without drusen (P = 0.011) [198]. The gene discussed is ARMS2; the disease is age-related macular degeneration.