CFB and age-related macular degeneration: After the discovery of these two loci for AMD, many studies evaluated various candidate genes and found several susceptibility genes for AMD such as C2/CFB, C3, and CFI. Furthermore, later GWASs have discovered more susceptibility genes [105,106,107,108,109], and the largest meta-analysis of GWASs has confirmed that 34 loci are associated with AMD development [110].