While this field is still in its infancy, some useful markers have emerged in the context of liver-derived EV isolation, which include asialoglycoprotein receptor 1 (ASGR1) or cytochrome P450 2E1 (CYP2E1), and have the potential to advance in vivo work in NAFLD [2]. The gene discussed is ASGR1; the disease is metabolic dysfunction-associated steatotic liver disease.