Compared with HCs, leptospirosis patients had significantly higher levels of plasma (p)FL-OPN (p < 0.0001), plasma thrombin-cleaved (ptr)-OPN (p < 0.01), pFL-Gal-9 (p < 0.0001), serum creatinine (sCr) (p < 0.0001), and serum cystatin C (sCyC) (p < 0.0001) (Figure 1). This evidence concerns the gene SPP1 and leptospirosis.