DEFA1 and leptospirosis: Given the importance of urinary markers in kidney injury associated with leptospirosis, urine defensin alpha 1, urine neutrophil gelatinase-associated lipocalin, and urine N-acetyl-β-d-glucosidase (uNAG)—markers of AKI and tubular dysfunction—are elevated in leptospirosis patients and reflect kidney damage [8].