It was reported that among patients admitted to the emergency department, plasma OPN level correlated well with sCr level and could be an independent predictor of sepsis; however, no difference was found between patients with and without AKI using an ELISA kit whose epitope was not disclosed but was found to react with both full-length and cleaved form of OPN [12,36,37]. The gene discussed is SPP1; the disease is Sepsis.