IL6 and Familial prostate cancer: There is a consistent body of evidence that relate testosterone deficiency to systemic inflammatory responses e.g., both animal studies and human studies showed that testosterone deficiency is associated with an increase in pro-inflammatory cytokines and testosterone substitution reduced pro-inflammatory cytokines in patients with coronary artery disease, prostate cancer and diabetes mellitus through the decrease in pro-inflammatory cytokines (IL-1β, IL-6, and TNF-alpha) [21,22].