Several genes were validated in APA sperm that were associated with autism spectrum disorder (CACNA1H, CNTNAP2, GRIN1, SHANK2, SHANK3, ZNF804A), schizophrenia (TCF3, ZNF804A), and bipolar disorder (COMT, DRD4, GRIN1, MBP, PRKCZ, SHANK2, TRPM2, ZNF804A), and in APA blastocysts (CACNA1H). The gene discussed is DRD4; the disease is autism spectrum disorder.