We also examined whether any of these genes displayed altered expression levels in AD versus control cells, and we observed that APOE, ABCA7, GPR141, PTK2B, SPI1, and ZYX appeared upregulated in AD microglia, whereas MEF2C appeared downregulated (unadjusted p < 0.05) (Figure 2B). Here, APOE is linked to Alzheimer disease.