APOE and Alzheimer disease: Therefore, another possible simi-laritybetweenDAMandHAMprofilescouldbetheinvolvementof lipid/lysosomal biology-associated genes.Several genesassoci-ated with AD incidence (APOE, CLU, ABCA7, SORL1, INPP5D, and PLCG2)(Jansen et al., 2019; Kunkle et al., 2019; Marioni et al., 2018) also function in lipid transport or signaling.