Conversely, we looked at whether the DE genes identified in HAM (besides APOE, a well-known DAM gene) showed consistent trends in mouse models of neurodegeneration (Friedman et al., 2018; Orre et al., 2014; Wang et al., 2015), infection (Erny et al., 2015; Srinivasan et al., 2016), and aging (Grabert et al., 2016). This evidence concerns the gene APOE and infection.