Loss‐of‐function (LOF) mutations in ORAI1 or STIM1 genes (OMIM 610277 and 605921) abolish SOCE and cause CRAC channelopathy, which is characterized by combined immunodeficiency (CID), humoral autoimmunity, and ectodermal dysplasia (Lacruz & Feske, 2015; Concepcion et al, 2016). This evidence concerns the gene STIM1 and combined immunodeficiency.