These SNPs include four missense variants, with the lowest overall MAF or with fixed ancestral alleles in several populations (associated with low iron: TMPRSS6 rs78174698 and TF rs1799899; associated with increased serum ferritin: SLC40A1 rs11568350; associated with haemochromatosis: HFE rs1800562). This evidence concerns the gene HFE and hereditary hemochromatosis.