PTGS2 and Renal insufficiency: NSAIDs impair neutrophil function and recruitment to the inflammatory site through cyclooxygenase-2 inhibition and may thus delay the resolution of inflammatory processes.18 In addition, NSAID use has been suggested to increase the risk of renal failure in critically ill patients19 and may also increase the risk of cardiovascular complications.20 Finally, NSAIDs may mask the earliest symptoms of an adverse outcome in pneumonia by relieving fever and pleural pain, potentially delaying medical assistance.