TNF and type 1 diabetes mellitus: This need for combination therapies with high curative potential in T1D is not so evident in other autoimmune diseases such as rheumatoid arthritis and inflammatory bowel diseases [10, 13, 24–28], where the more modest therapy goal, namely a symptom-free remission of the disease, can be reached in many cases also with an anti-cytokine monotherapy, such as with anti-TNF-α [25, 26, 29, 30].