The multi-organ failure observed in many patients is considered the result of a pro-inflammatory cytokine storm, including IL1β, IL2, IL6, IL7, IL8, IL10, IL17, and interferon gamma, probably accompanied by diffuse macrophage activation, as also evidenced by the presence of hemophagocytosis in liver tissue of our patients [9]. The gene discussed is IL1B; the disease is Hemophagocytosis.