These proteins are typically associated with the immune system and inflammation and have been found to increase during pregnancy in giant pandas and humans (ceruloplasmin; Derzsy et al., 2010; Willis et al., 2011), during successful fertilization in humans (fetuin-B; Floehr et al., 2016) and during the early stages of pregnancy when individuals are developing preeclampsia (afamin; Köninger et al., 2018). The gene discussed is AFM; the disease is preeclampsia.