Strikingly, we found that the IRLS high-risk group were filled with all types of immune cells, especially immunosuppressive cells such as Treg, macrophages and NK CD56dim cells, which could formed the immunosuppressive atmosphere to hamper the activation of CD8 + T cells and NK CD56bright cells for eradicating the tumour cells [56, 57]. The gene discussed is CD8A; the disease is neoplasm.