The potential target miRNA was investigated to explore the molecular mechanism through which LINC00261 suppresses the cell proliferation and metastasis of LC cells, and we found that in LC cells LINC00261 was a sponge for miR-1269a, and that FOXO1 was target gene for miR-1269a. Here, FOXO1 is linked to laryngotracheoesophageal cleft.