SPX and obesity due to melanocortin 4 receptor deficiency: In agreement with these findings, the present study demonstrated that circulating levels of spexin were decreased with obesity and diabetes in adults and negatively correlated with adiposity markers (BMI and waist and hip circumference), DBP, systolic blood pressure (SBP) and lipid markers (LDL, TG and TC) but positively correlated with HDL levels.