Mos inhibits the coalescence of supernumerary centrosomes to induce frequent tetraploidization, and knockdown of Mos stagnates multipolar mitoses and drives CIN in p53–/– cells.48 Taken together, these findings indicate that there is not a simple correspondence between the production of additional centrosomes and the continued maintenance of extra centrosomes. The gene discussed is MOS; the disease is cervical squamous intraepithelial neoplasia.