FBXW7 and neoplasm: The nuclear localization of tRF-5 and its relationship with Ago proteins suggest that some tRFs may act in chromatin regulation.63 CU1276, a tRF dependent on Dicer1 enzymatic shearing, participates in the regulation of B-lymphocyte proliferation by acting as an miRNA; in lymphoma, downregulating the expression of CU1276 can alleviate DNA damage, thereby reducing the accumulation of tumor mutants and improving the tolerance of cells to chromosomal aberrations.64