tRFLeu-CAG has a clear correlation with the stage of lung cancer, and repressing the expression of tRFLeu-CAG can inhibit cell proliferation and prevent cell-cycle progression.27 In ovarian cancer, tRF-5, produced by tRNAGlu-CTC, binds to the 3′UTR site of breast cancer anti-estrogen resistance 3 (BCAR3) mRNA, which suppresses the expression of BCAR3, thereby inhibiting the proliferation of ovarian cancer cells.74 The gene discussed is BCAR3; the disease is breast cancer.