tRF⁃1001, a type of tRF-1 from the 3′ end of precursor tRNASer, is necessary for tumor cell growth.56 Knocking down tRF-1001 can interfere with cell proliferation, arrest cells in the G2 phase, and inhibit DNA biosynthesis.57 Moreover, Hauseecker et al. found a specific correlation between tRF-1001 and Ago proteins, especially Ago3 and Ago4.58 The gene discussed is TERF1; the disease is neoplasm.