The nuclear localization of tRF-5 and its relationship with Ago proteins suggest that some tRFs may act in chromatin regulation.63 CU1276, a tRF dependent on Dicer1 enzymatic shearing, participates in the regulation of B-lymphocyte proliferation by acting as an miRNA; in lymphoma, downregulating the expression of CU1276 can alleviate DNA damage, thereby reducing the accumulation of tumor mutants and improving the tolerance of cells to chromosomal aberrations.64 This evidence concerns the gene TERF1 and neoplasm.