To that end, we sought to determine the role of the tumour suppressor cyclin dependent kinase 5 (CDK5) regulatory subunit-associated protein 3 (CDK5RAP3, also called C53/LZAP) in gastric CSCs.11,12 We surmised that CDK5RAP3 could be important in regulating the self-renewal of gastric CSCs based on our previous studies, which showed that it inhibits Wnt/β-catenin signalling in gastric cancer.13,14 As dysregulation of Wnt/β-catenin signalling is a tumour-initiating event, these finding supports am as-yet unstudied function of CDK5RAP3 in gastric CSCs. The gene discussed is CDK5RAP3; the disease is gastric cancer.