CDK5RAP3 and neoplasm: Toward evaluating the potential function of CDK5RAP3 in gastric CSCs, we first examined the relationship between CDK5RAP3 and CD44 expression in tumour tissue and adjacent nontumour tissue by IHC in paraffin-embedded specimens from 125 patients undergoing radical gastrectomy at FMUUH (Supplementary Fig. S1A).