HSPG2 and acute myeloid leukemia: ROC curve was used to examine the diagnostic value of HSPG2 in AML patients compared with healthy controls and found the AUC value to be 0.903 in whole-cohort AML (95% confidence interval (CI): 0.842–0.965, P < 0.001; Fig. 3a) with a sensitivity of 88.0% and a specificity of 74.1%, which indicated that HSPG2 could be a potential biomarker for distinguishing AML patients from healthy controls.