Here, PanNENs that belong to the G3 group are defined as either well-differentiated with a Ki-67 > 20%, pancreatic neuroendocrine tumour grade 3 (PanNET G3) or as poorly differentiated pancreatic neuroendocrine carcinoma (PanNEC) with Ki-67 > 20%. The gene discussed is MKI67; the disease is pancreatic endocrine carcinoma.