Inhibition of β-catenin-dependent transcriptional activation with the specific inhibitors of β-catenin/TCF-LEF interaction, iCRT5 or FH53525,26, also exclusively increased apoptosis in HUVEC under DF in the same conditions (Figs. 5d and S3e) and in HAEC exposed to DF (Fig. S3f). The gene discussed is HNF4A; the disease is dengue disease.