Our results showed that FOXP3 tends to be more expressed in PTC cases with large tumor size, advanced tumor stage, presence of lymph node metastasis, and extracapsular extension with a highly statistically significant difference (p < 0.001).These results in line with Ugolini et al., who found in their study thatFOXP3 immunostaining was associated with finding distant spread and extension outside the thyroid gland22. Here, FOXP3 is linked to neoplasm.