It also has been shown that the combination of high Lp(a) plasma level and carrier status of the apolipoprotein E (APOE) epsilon 4 allele increases the risk for late-onset Alzheimer ́s disease, while Lp(a) might protect against this decline in APOE-4 non-carriers23. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.