GPX4 and cancer: The eoxPLs, such as 15-hydroxyeicosatetraenoic acid (15-HETE), oxidized AA-PE and AdA-PE, which are produced by the ACSL4/LPCAT3/15-LOX axis, promote ferroptosis.55,101,102 In addition, the cells release oxidized lipid mediators such as 5-HETE, 11-HETE and 15-HETE during GPX4 deletion-induced ferroptosis.102 Hence, AA metabolites may be the potential “find me” signals to recruit immune cells to find ferroptotic cancer cells.