ACSL4 and Familial prostate cancer: ACSL4 ablation significantly abolishes IR-induced ferroptosis and promotes radioresistance.90 In addition, inhibiting 12-LOX can modulate the radiosensitivity of human prostate cancer cells,91 suggesting that the P53/12-LOX-mediated, ACSL4-independent ferroptosis pathway may be involved in the regulation of radioresistance.