Osteosarcoma cells are unable to form ETC-dependent ROS due to the absence of mitochondrial DNA-encoded transcripts, but these cells remain sensitive to erastin as corresponding mtDNA wildtype cells.4 Secondly, AA and AdA are oxidized to LPO under the catalysis of ACSL4, lysophosphatidylcholine acyltransferase 3 (LPCAT3) and 15-LOX. The gene discussed is LPCAT3; the disease is osteosarcoma.