HELLS and cancer: Hypoxia-inducible factor-1 (HIF-1) is a crucial factor which plays an important role in the development of cancer, and it is well known to regulate glycolysis, lipid metabolism and glutaminolysis.57,58 The iron-dependent enzymes Egl-9 family hypoxia-inducible factor 1/3 (EGLN1/3) and c-Myc directly activate the expression of chromatin remodeling factor lymphoid-specific helicase (LSH) by suppressing HIF-1α in lung cancer progression.