To determine whether MSI2 protein interacts with CAV1 protein in cell lines, we performed co-immunoprecipitation experiments in ST8814 cell using the MSI2 antibody, and we found that CAV1 could be pulled down; further, the CAV1 antibody was used to pull down MSI2 (Fig. 2d), confirming the interaction between MSI2 and CAV1 in NF1-MPNST cells. This evidence concerns the gene CAV1 and malignant peripheral nerve sheath tumor.