We first detected the correlation between MSI2 and CAV1 expression in two GEO databases and found that the CAV1 score is negatively correlated with the MSI2 score in two MPNST patient cohorts, Jessen_cohort (GEO: GSE41747) and Kolberg_cohort (GEO: GSE66743) (Fig. 3a, b). The gene discussed is CAV1; the disease is malignant peripheral nerve sheath tumor.