First, through co-immunoprecipitation (IP) and mass spectrometry analysis, we found that MSI2 protein can interact with CAV1 protein.While MSI2 is an RNA binding protein and we found that MSI2 did not bind with CAV1 mRNA and did not affect CAV1 transcription level.Previous study found that CAV1 can be regulated through ubiquitylation to induce or inhibit tumour cell activity. This evidence concerns the gene MSI2 and neoplasm.