UCP1 and metabolic syndrome: The results suggest that, besides its well-known effects in targeting “HMG-CoA reductase”, simvastatin co-treatment may ameliorate olanzapine-induced dyslipidemia through inhibiting SREBP-controlled HMG-CoA reductase activation, and modulating the transcriptional responses of thermogenic genes, at least in part, to increase energy expenditure via upregulation of UCP1.