DVL1 and cancer: In a study by Ding et al. [147] on NEDD4L inhibitory effects on the Wnt signaling, it was noted that NEDD4L is often found to be downregulated in cancers, while its Wnt-target Dvl (disheveled), which is modified by NEDD4L for proteasomal degradation, is often upregulated in the same cancers [147].