ESR1 and breast cancer: Collectively, combining information from COSMIC and CancerMine, with results of DE analysis, network analysis, and WGCNA, confirmed that genes from the green module were specifically related to breast cancer subtype (ER, PGR, and Her2 status), which genes in the yellow module represented tumor immune infiltration (hub gene PTPRC is a tumor suppressor in T cell acute lymphoblastic leukemia), while genes in the blue module were related to progression and metastasis.