Eleven PAM50 genes had been annotated in the COSMIC cancer gene census, out of which seven (BCL2, CCNE1, EGFR, ERBB2, ESR1, FOXA1, and FOXC1) were found to be DE in our analysis, all with a consensus of cardinality between subtypes—Fig. 6b. The gene discussed is EGFR; the disease is cancer.