EPB41L5 and brain cancer: However, EPB41L5 and SERINC3 had a high rank based on mutational burden and CNVs, ELOVL6 was annotated as an oncogene in prostate cancer, and PPM1H has been proposed to be an oncogene, due to its relation to PPM1D (a well-studied oncogene in breast, ovarian, and brain cancers).