Overexpression of CHST3 and CHST11 have been linked to BC aggressiveness, relapse, and development of metastasis [164]; in contrast, downregulation of CHST10 and CHST14 has been linked to invasive melanoma and to late stages of colon cancer progression, respectively [165, 166]. The gene discussed is CHST14; the disease is malignant colon neoplasm.