BGLAP and osteoporosis: However, osteocalcin and beta-CTX were significantly increased (osteocalcin 51.46 ng/mL, normal range: 11–46 ng/ml; beta-CTX 2105.00 ng/L, normal range:< 573 ng/L), and bone mineral density (BMD) demonstrated severe osteoporosis (Z-score: L1–4 BMD − 2.8, Neck BMD − 0.7), which indicated high bone turn-over rate in this patient.