TGFB1 and colorectal cancer: In the seminal “consensus molecular subtyping of colorectal cancer” study [5], the consensus molecular subtype (CMS) 4 was noted with mesenchymal, stromal infiltration, TGFβ activation, angiogenesis, and worse relapse-free and overall survival; CMS1 was depicted as MSI/CIMP high, immune infiltration and activation, and worse survival after relapse.