An interaction network analysis of the top 100 DM CpG sites showed five common regulator genes: nemo-like kinase (NLK), calcium/calmodulin-dependent protein kinase 1 (CAMKK1), lysophosphatidic acid receptor 2 (LPAR2), caspase 1 (CASP1), and Nance-Horan syndrome (NHS). Here, CASP1 is linked to Nance-Horan syndrome.